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Partner with a team that has decades of peer-reviewed experience in transgenics. Our body of evidence continues to grow across a diverse range of platforms and applications.

Recent publications from IDeal Genetics and our clients

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Tan D.C.S., Yao S., Ittner A., Bertz J., Ke Y.D., Ittner L.M., Delerue F. (2018). Generation of a New Tau Knockout (tauΔex1) Line Using CRISPR/Cas9 Genome Editing in Mice. Journal of Alzheimer’s Disease. 62(2):571-578. doi: 10.3233/JAD-171058.

Delerue F., Ittner L.M. (2017) Generation of Genetically Modified Mice through the Microinjection of Oocytes. Journal of Visualized Experiments Jun 15;(124). doi: 10.3791/55765

Pleines I… Delerue F., Ittner L.M., Bryce N.S., Holliday M., Lucas C.A., Hardeman E.C., Ouwehand W.H., Gunning P.W., Turro E., Tijssen M.R., Kile B.T. (2017). Mutations in Tropomyosin 4 underlie a novel form of human macrothrombocytopenia. Journal of Clinical Investigations Mar 1;127(3):814-829. doi: 10.1172/JCI86154.

Ittner A., Chua S.W., Bertz J., Volkerling A., van der Hoven J., Gladbach A., Przybyla M., Bi M., van Hummel A., Stevens C.H., Ippati S., Suh L.S., Macmillan A., Sutherland G., Kril J.J., Silva A.P., Mackay J.P., Poljak A., Delerue F., Ke Y.D., Ittner L.M. (2016). Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s mice. Science Nov 18;354(6314):904-908.doi: 10.1126/science.aah6205

Chandrakanthan V… Delerue F., Ittner L.M., Mobbs R., Walkley C.R., Purton L.E., Ward R.L., Wong J.W., Hesson L.B., Walsh W., Pimanda J.E. (2016). PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proceedings of the National Academy of Sciences of the United States of America.Apr 19;113(16):E2306-15. doi: 10.1073/pnas.1518244113.

Ke Y.D., van Hummel A., Stevens C.H., Gladbach A., Ippati S., Bi M., Lee W.S., Krüger S., van der Hoven J., Volkerling A., Bongers A., Halliday G., Haass N.K., Kiernan M., Delerue F., Ittner L.M. (2015). Short-term suppression of A315T mutant human TDP-43 expression improves functional deficits in a novel inducible transgenic mouse model of FTLD-TDP and ALS. Acta Neuropathologica Nov;130(5):661-78. doi: 10.1007/s00401-015-1486-0

Delerue F. & Ittner LM. (2015). Genome Editing in Mice Using CRISPR/Cas9: Achievements and Prospects. Cloning and Transgenesis 4:135. doi:10.4172/2168-9849.1000135.

Delerue F., White M., Ittner L.M. (2014). Inducible, tightly regulated and non-leaky neuronal gene expression in mice. Transgenic Research. Apr;23(2):225-33. doi: 10.1007/s11248-013-9767-7.

Ittner L.M., Ke Y.D., Delerue F., Bi M., Gladbach A., van Eersel J., Wölfing H., Chieng B.C., Christie M.J., Napier I.A., Eckert A., Staufenbiel M., Hardeman E., Götz J. (2010). Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer’s disease mouse models. Cell Aug 6;142(3):387-97. doi: 10.1016/j.cell.2010.06.036.

Ittner L.M., Götz J. (2007). Pronuclear injection for the production of transgenic mice. Nature Protocols 2(5):1206-15.doi: 10.1038/nprot.2007.145

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